Reaction Details |
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Target | Glucokinase regulatory protein |
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Ligand | BDBM50009090 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1338435 (CHEMBL3240701) |
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IC50 | 25000±n/a nM |
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Citation | Nishimura, N; Norman, MH; Liu, L; Yang, KC; Ashton, KS; Bartberger, MD; Chmait, S; Chen, J; Cupples, R; Fotsch, C; Helmering, J; Jordan, SR; Kunz, RK; Pennington, LD; Poon, SF; Siegmund, A; Sivits, G; Lloyd, DJ; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J Med Chem57:3094-116 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucokinase regulatory protein |
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Name: | Glucokinase regulatory protein |
Synonyms: | GCKR | GCKR_HUMAN | GKRP | Glucokinase regulator |
Type: | PROTEIN |
Mol. Mass.: | 68685.97 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_103091 |
Residue: | 625 |
Sequence: | MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI
FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV
GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ
KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE
RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ
TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR
AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA
VRSALAGPGQKRTADPLEILEPDVQ
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BDBM50009090 |
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n/a |
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Name | BDBM50009090 |
Synonyms: | CHEMBL3237978 |
Type | Small organic molecule |
Emp. Form. | C18H20N4O2S |
Mol. Mass. | 356.442 |
SMILES | CC#C[C@H]1CN(CCN1c1ccccc1)S(=O)(=O)c1ccc(N)nc1 |r| |
Structure |
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