| Reaction Details |
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 | Report a problem with these data |
| Target | Glucokinase regulatory protein |
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| Ligand | BDBM50009094 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1338435 (CHEMBL3240701) |
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| IC50 | 35±n/a nM |
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| Citation |  Nishimura, N; Norman, MH; Liu, L; Yang, KC; Ashton, KS; Bartberger, MD; Chmait, S; Chen, J; Cupples, R; Fotsch, C; Helmering, J; Jordan, SR; Kunz, RK; Pennington, LD; Poon, SF; Siegmund, A; Sivits, G; Lloyd, DJ; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J Med Chem57:3094-116 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucokinase regulatory protein |
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| Name: | Glucokinase regulatory protein |
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| Synonyms: | GCKR | GCKR_HUMAN | GKRP | Glucokinase regulator |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68685.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103091 |
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| Residue: | 625 |
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| Sequence: | MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI
FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV
GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ
KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE
RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ
TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR
AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA
VRSALAGPGQKRTADPLEILEPDVQ
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| BDBM50009094 |
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| n/a |
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| Name | BDBM50009094 |
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| Synonyms: | CHEMBL3237993 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N5O4S2 |
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| Mol. Mass. | 449.547 |
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| SMILES | CNS(=O)(=O)c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1 |r| |
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| Structure | 
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