Reaction Details |
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Target | Glucokinase regulatory protein |
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Ligand | BDBM50009117 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1338436 (CHEMBL3240702) |
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EC50 | 145±n/a nM |
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Citation | Nishimura, N; Norman, MH; Liu, L; Yang, KC; Ashton, KS; Bartberger, MD; Chmait, S; Chen, J; Cupples, R; Fotsch, C; Helmering, J; Jordan, SR; Kunz, RK; Pennington, LD; Poon, SF; Siegmund, A; Sivits, G; Lloyd, DJ; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J Med Chem57:3094-116 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucokinase regulatory protein |
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Name: | Glucokinase regulatory protein |
Synonyms: | GCKR_MOUSE | Gckr | Glucokinase regulator |
Type: | PROTEIN |
Mol. Mass.: | 64679.62 |
Organism: | Mus musculus |
Description: | ChEMBL_108288 |
Residue: | 587 |
Sequence: | MPSTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVQLLGQCDAEI
FQEEGQIMPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASRERTEDSALHGIEELKKVAAGKKRVVVIGISV
GLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQ
EAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFE
RAHQVTYSQSSKIATLTKQVGISLEKKGHVHLVGWQTLGIIAIMDGVECIHTFGADFRDI
RGFLIGDHNDMFNQKDELSNQGPQFTFSQDDFLTSVLPSLTEIDTVVFIFTLDDNLAEVQ
ALAERVREKSWNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGSYVQKFQREL
STKWVLNTRFSGQSKARCIESLLQVIHFPQPLSNDVRAAPISCHVQVAHEKEKVIPTALL
SLLLRCSITEAKERLAAASSVCEVVRSALSGPGQKRSIQAFGDPVVP
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BDBM50009117 |
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n/a |
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Name | BDBM50009117 |
Synonyms: | CHEMBL3238312 |
Type | Small organic molecule |
Emp. Form. | C20H22F3N5O4S |
Mol. Mass. | 485.48 |
SMILES | CC#C[C@H]1CN(CCN1c1ccc(cn1)C(O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r| |
Structure |
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