| Reaction Details |
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 | Report a problem with these data |
| Target | Transporter |
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| Ligand | BDBM50009717 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1344246 (CHEMBL3256076) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Martin, LL; Klioze, SS; Worm, M; Crichlow, CA; Geyer, HM; Kruse, H Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 5. Conformationally mobile analogues derived by furan ring opening. J Med Chem22:1347-54 (1980) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Transporter |
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| Name: | Transporter |
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| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69236.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q63380 |
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| Residue: | 617 |
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| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
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| BDBM50009717 |
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| n/a |
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| Name | BDBM50009717 |
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| Synonyms: | CHEMBL436281 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19NO |
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| Mol. Mass. | 265.3496 |
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| SMILES | C1CC2(CCN1)OC(c1ccccc21)c1ccccc1 |
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| Structure | 
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