| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 4 |
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| Ligand | BDBM50011370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1352357 (CHEMBL3269774) |
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| EC50 | 790±n/a nM |
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| Citation |  Neve, JE; Wijesekera, HP; Duffy, S; Jenkins, ID; Ripper, JA; Teague, SJ; Campitelli, M; Garavelas, A; Nikolakopoulos, G; Le, PV; de A Leone, P; Pham, NB; Shelton, P; Fraser, N; Carroll, AR; Avery, VM; McCrae, C; Williams, N; Quinn, RJ Euodenine A: a small-molecule agonist of human TLR4. J Med Chem57:1252-75 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 4 |
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| Name: | Toll-like receptor 4 |
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| Synonyms: | TLR4 | TLR4-MD2 | TLR4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95675.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1436169 |
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| Residue: | 839 |
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| Sequence: | MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
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| BDBM50011370 |
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| n/a |
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| Name | BDBM50011370 |
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| Synonyms: | CHEMBL3261022 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33NO5 |
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| Mol. Mass. | 463.5653 |
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| SMILES | [H][C@@]12[C@@H]([C@@H](C(C)C)[C@]1([H])C(C)(C)Oc1c2c(=O)[nH]c2ccccc12)c1cc(OC)c(OC)c(OC)c1 |r| |
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| Structure | 
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