| Reaction Details |
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 | Report a problem with these data |
| Target | Fatty-acid amide hydrolase 1 |
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| Ligand | BDBM50012157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1352948 (CHEMBL3269815) |
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| IC50 | 70.0±n/a nM |
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| Citation |  Duncan, KK; Otrubova, K; Boger, DL a-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain. Bioorg Med Chem22:2763-70 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fatty-acid amide hydrolase 1 |
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| Name: | Fatty-acid amide hydrolase 1 |
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| Synonyms: | Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH1_MOUSE | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1 |
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| Type: | Hydrolase; single-pass membrane protein; homodimer |
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| Mol. Mass.: | 63227.28 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Mouse brain membranes were used in the assay. |
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| Residue: | 579 |
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| Sequence: | MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQ
RFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTD
CETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAV
PFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCE
DLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTL
VPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSF
LLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALD
LNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMK
KGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
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| BDBM50012157 |
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| n/a |
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| Name | BDBM50012157 |
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| Synonyms: | CHEMBL3264462 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18N2O4 |
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| Mol. Mass. | 398.4107 |
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| SMILES | O=C(C1CCc2cc(Oc3ccccc3)ccc2O1)c1ncc(o1)-c1ccccn1 |
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| Structure | 
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