| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 2 |
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| Ligand | BDBM50012640 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1351639 (CHEMBL3269326) |
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| IC50 | 11060±n/a nM |
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| Citation |  Oehlrich, D; Prokopcova, H; Gijsen, HJ The evolution of amidine-based brain penetrant BACE1 inhibitors. Bioorg Med Chem Lett24:2033-45 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 2 |
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| Name: | Beta-secretase 2 |
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| Synonyms: | BACE2_RAT | Bace2 | Beta-site APP cleaving enzyme 2 | Beta-site amyloid precursor protein cleaving enzyme 2 | Memapsin-1 | Membrane-associated aspartic protease 1 | Theta-secretase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55848.42 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1351639 |
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| Residue: | 514 |
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| Sequence: | MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGL
ALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHS
YIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE
NFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGT
NGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDS
GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRD
ENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQR
RVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILL
VLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
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| BDBM50012640 |
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| n/a |
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| Name | BDBM50012640 |
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| Synonyms: | CHEMBL2403779 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16ClFN4O2 |
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| Mol. Mass. | 374.797 |
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| SMILES | [H][C@@]12C[C@@]1(N=C(N)COC2)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |r,t:5| |
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| Structure | 
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