| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-secretase 2 |
|---|
| Ligand | BDBM50012641 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1351639 (CHEMBL3269326) |
|---|
| IC50 | 5020±n/a nM |
|---|
| Citation |  Oehlrich, D; Prokopcova, H; Gijsen, HJ The evolution of amidine-based brain penetrant BACE1 inhibitors. Bioorg Med Chem Lett24:2033-45 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-secretase 2 |
|---|
| Name: | Beta-secretase 2 |
|---|
| Synonyms: | BACE2_RAT | Bace2 | Beta-site APP cleaving enzyme 2 | Beta-site amyloid precursor protein cleaving enzyme 2 | Memapsin-1 | Membrane-associated aspartic protease 1 | Theta-secretase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55848.42 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1351639 |
|---|
| Residue: | 514 |
|---|
| Sequence: | MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGL
ALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHS
YIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE
NFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGT
NGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDS
GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRD
ENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQR
RVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILL
VLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
|
|
|
|---|
| BDBM50012641 |
|---|
| n/a |
|---|
| Name | BDBM50012641 |
|---|
| Synonyms: | CHEMBL3261061 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22ClFN4O2 |
|---|
| Mol. Mass. | 452.908 |
|---|
| SMILES | C[C@]1(C[C@H](OCC(N)=N1)c1ccccc1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |r,c:7| |
|---|
| Structure | 
|
|---|
Search and Browse
