Reaction Details |
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Target | Beta-secretase 2 |
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Ligand | BDBM50012643 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1351639 (CHEMBL3269326) |
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IC50 | 5.0±n/a nM |
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Citation | Oehlrich, D; Prokopcova, H; Gijsen, HJ The evolution of amidine-based brain penetrant BACE1 inhibitors. Bioorg Med Chem Lett24:2033-45 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 2 |
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Name: | Beta-secretase 2 |
Synonyms: | BACE2_RAT | Bace2 | Beta-site APP cleaving enzyme 2 | Beta-site amyloid precursor protein cleaving enzyme 2 | Memapsin-1 | Membrane-associated aspartic protease 1 | Theta-secretase |
Type: | PROTEIN |
Mol. Mass.: | 55848.42 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1351639 |
Residue: | 514 |
Sequence: | MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGL
ALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHS
YIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE
NFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGT
NGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDS
GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRD
ENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQR
RVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILL
VLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
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BDBM50012643 |
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n/a |
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Name | BDBM50012643 |
Synonyms: | CHEMBL3261062 |
Type | Small organic molecule |
Emp. Form. | C18H16ClF3N4O2 |
Mol. Mass. | 412.793 |
SMILES | C[C@@]1(N=C(N)COCC1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |r,t:2| |
Structure |
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