Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBcl-2-related protein A1
LigandBDBM50013867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1349699 (CHEMBL3266883)
Ki 3360±n/a nM
Citation Abulwerdi, FALiao, CMady, ASGavin, JShen, CCierpicki, TStuckey, JAShowalter, HDNikolovska-Coleska, Z 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem57:4111-33 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-related protein A1
Name:Bcl-2-related protein A1
Synonyms:B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:Apoptosis regulator protein
Mol. Mass.:20130.01
Organism:Homo sapiens (Human)
Description:n/a
Residue:175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50013867
n/a
NameBDBM50013867
Synonyms:CHEMBL3265299
TypeSmall organic molecule
Emp. Form.C24H19NO6S2
Mol. Mass.481.541
SMILESOC(=O)CSc1cc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)c2ccccc2c1O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: