| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50016982 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364745 (CHEMBL3294006) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Scott, JS; Goldberg, FW; Turnbull, AV Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). J Med Chem57:4466-86 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32369.70 |
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| Organism: | Mus musculus (mouse) |
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| Description: | P50172 |
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| Residue: | 292 |
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| Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
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| BDBM50016982 |
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| n/a |
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| Name | BDBM50016982 |
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| Synonyms: | CHEMBL3287027 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27Cl3N4O4S |
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| Mol. Mass. | 549.898 |
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| SMILES | NC(=O)[C@@]12CC3CC(C[C@](C3)(C1)NC(=O)CN1CCCN(c3c(Cl)cc(Cl)cc3Cl)S1(=O)=O)C2 |r,TLB:33:3:8.7.6:10,THB:33:7:10:11.3.4,4:3:8:6.5.10,4:5:8:11.33.3,1:3:8:6.5.10,1:3:8.7.6:10| |
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| Structure | 
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