Reaction Details |
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Target | Sphingosine kinase 2 |
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Ligand | BDBM50017017 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1365139 (CHEMBL3292346) |
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Ki | 4200±n/a nM |
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Citation | Plano, D; Amin, S; Sharma, AK Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. J Med Chem57:5509-24 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine kinase 2 |
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Name: | Sphingosine kinase 2 |
Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
Type: | Protein |
Mol. Mass.: | 69221.44 |
Organism: | Homo sapiens (Human) |
Description: | Q9NRA0 |
Residue: | 654 |
Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
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BDBM50017017 |
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n/a |
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Name | BDBM50017017 |
Synonyms: | CHEMBL3287037 |
Type | Small organic molecule |
Emp. Form. | C25H28ClNO3 |
Mol. Mass. | 425.948 |
SMILES | Oc1ccc(CCNC(=O)C23CC4CC(C2)CC(C4)(C3)c2ccc(Cl)cc2)cc1O |TLB:18:17:11.12.13:15,THB:18:12:15:19.17.16,16:17:11:13.14.15,16:14:11:19.18.17,20:17:11:13.14.15,20:17:11.12.13:15| |
Structure |
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