Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017304 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.015849±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017304 | |||
n/a | |||
Name | BDBM50017304 | ||
Synonyms: | CHEMBL3287991 | ||
Type | Small organic molecule | ||
Emp. Form. | C34H36FN5O5S | ||
Mol. Mass. | 645.744 | ||
SMILES | Cc1csc(n1)C(=O)N[C@H]1CC[C@H](CC1)NC(=O)c1cc(F)cnc1Oc1cccc(c1)-c1ccc(O)cc1CN1CCOCC1 |r,wU:9.9,12.16,(40.08,-42.78,;38.55,-42.67,;37.73,-41.37,;36.21,-41.6,;36.13,-43.26,;37.56,-43.85,;34.83,-44.08,;34.83,-45.62,;33.5,-43.3,;32.16,-44.08,;32.15,-45.62,;30.83,-46.38,;29.49,-45.61,;29.48,-44.08,;30.82,-43.3,;28.16,-46.38,;26.82,-45.62,;26.82,-44.08,;25.49,-46.39,;24.16,-45.63,;22.82,-46.4,;21.49,-45.63,;22.82,-47.94,;24.16,-48.72,;25.5,-47.94,;26.83,-48.71,;26.83,-50.25,;25.5,-51.02,;25.5,-52.56,;26.84,-53.33,;28.17,-52.55,;28.16,-51.01,;29.51,-53.31,;29.51,-54.85,;30.85,-55.61,;32.18,-54.84,;33.51,-55.6,;32.16,-53.29,;30.83,-52.53,;30.82,-50.99,;32.14,-50.21,;33.48,-50.97,;34.81,-50.2,;34.8,-48.65,;33.45,-47.89,;32.12,-48.68,)| | ||
Structure |