Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017305 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.063096±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017305 | |||
n/a | |||
Name | BDBM50017305 | ||
Synonyms: | CHEMBL3287992 | ||
Type | Small organic molecule | ||
Emp. Form. | C34H36FN5O6S | ||
Mol. Mass. | 661.743 | ||
SMILES | OCc1nc(cs1)C(=O)N[C@H]1CC[C@H](CC1)NC(=O)c1cc(F)cnc1Oc1cccc(c1)-c1ccc(O)cc1CN1CCOCC1 |r,wU:10.10,13.17,(22.02,-3.74,;21.3,-5.09,;19.76,-5.14,;18.89,-6.41,;17.41,-5.97,;17.36,-4.44,;18.81,-3.92,;16.2,-6.92,;16.2,-8.46,;14.86,-6.14,;13.52,-6.92,;13.52,-8.46,;12.19,-9.22,;10.85,-8.45,;10.85,-6.92,;12.18,-6.14,;9.52,-9.22,;8.18,-8.46,;8.18,-6.92,;6.85,-9.23,;5.52,-8.47,;4.18,-9.24,;2.85,-8.47,;4.18,-10.78,;5.52,-11.56,;6.86,-10.78,;8.19,-11.56,;8.2,-13.1,;6.86,-13.86,;6.86,-15.4,;8.2,-16.18,;9.54,-15.39,;9.53,-13.85,;10.87,-16.15,;10.88,-17.7,;12.21,-18.46,;13.54,-17.68,;14.88,-18.44,;13.53,-16.13,;12.19,-15.37,;12.18,-13.83,;13.51,-13.06,;14.84,-13.82,;16.17,-13.05,;16.16,-11.51,;14.83,-10.75,;13.49,-11.52,)| | ||
Structure |