Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017310 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.050119±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017310 | |||
n/a | |||
Name | BDBM50017310 | ||
Synonyms: | CHEMBL3287996 | ||
Type | Small organic molecule | ||
Emp. Form. | C36H37FN6O4 | ||
Mol. Mass. | 636.7152 | ||
SMILES | CN(C)Cc1cc(O)ccc1-c1cccc(Oc2ncc(F)cc2C(=O)N[C@@H]2CC[C@@H](CC2)NC(=O)c2cn3c(C)cccc3n2)c1 |r,wU:30.35,27.28,(12.31,-47.81,;10.97,-47.04,;10.96,-45.5,;9.64,-47.81,;9.66,-49.36,;10.99,-50.12,;11.01,-51.67,;12.35,-52.42,;9.67,-52.44,;8.34,-51.68,;8.33,-50.14,;7,-49.37,;5.66,-50.16,;4.32,-49.38,;4.32,-47.84,;5.66,-47.08,;5.65,-45.54,;4.32,-44.76,;2.98,-45.54,;1.64,-44.76,;1.64,-43.22,;.31,-42.45,;2.98,-42.45,;4.31,-43.21,;5.65,-42.44,;5.64,-40.9,;6.98,-43.2,;8.31,-42.43,;9.66,-43.2,;10.98,-42.44,;10.98,-40.89,;9.65,-40.12,;8.31,-40.9,;12.33,-40.12,;13.66,-40.89,;13.66,-42.43,;14.88,-39.94,;14.83,-38.42,;16.28,-37.9,;16.85,-36.48,;15.91,-35.27,;18.37,-36.27,;19.32,-37.49,;18.74,-38.91,;17.22,-39.11,;16.36,-40.39,;6.99,-47.84,)| | ||
Structure |