Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017315 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.031623±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017315 | |||
n/a | |||
Name | BDBM50017315 | ||
Synonyms: | CHEMBL3288001 | ||
Type | Small organic molecule | ||
Emp. Form. | C38H41FN4O6 | ||
Mol. Mass. | 668.7537 | ||
SMILES | Cc1cccc(O)c1C(=O)N[C@@H]1CC[C@@H](CC1)NC(=O)c1cc(F)cnc1Oc1cccc(c1)-c1ccc(O)cc1CN1CCCOCC1 |r,wU:11.11,14.18,(55.81,-27.02,;55.81,-25.48,;57.14,-24.72,;57.14,-23.18,;55.8,-22.41,;54.48,-23.18,;53.15,-22.42,;54.49,-24.71,;53.16,-25.48,;53.16,-27.02,;51.82,-24.7,;50.48,-25.48,;49.14,-24.7,;47.8,-25.48,;47.81,-27.02,;49.15,-27.79,;50.48,-27.02,;46.47,-27.79,;45.14,-27.03,;45.13,-25.48,;43.8,-27.8,;42.47,-27.04,;41.13,-27.81,;39.8,-27.04,;41.13,-29.35,;42.47,-30.13,;43.81,-29.35,;45.15,-30.12,;45.15,-31.67,;43.81,-32.43,;43.81,-33.97,;45.15,-34.75,;46.49,-33.96,;46.48,-32.42,;47.83,-34.73,;47.83,-36.27,;49.17,-37.03,;50.5,-36.26,;51.84,-37.02,;50.49,-34.71,;49.15,-33.95,;49.14,-32.4,;50.47,-31.63,;50.34,-30.1,;51.46,-29.04,;52.99,-29.25,;53.76,-30.58,;53.21,-32.02,;51.74,-32.48,)| | ||
Structure |