Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017333 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.031623±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
| ||
BDBM50017333 | |||
n/a | |||
Name | BDBM50017333 | ||
Synonyms: | CHEMBL3288022 | ||
Type | Small organic molecule | ||
Emp. Form. | C37H44FN7O4 | ||
Mol. Mass. | 669.7882 | ||
SMILES | C[C@H]1CN(Cc2ccc(cc2O)-c2cccc(Oc3ncc(F)cc3C(=O)N[C@@H]3CC[C@@H](CC3)NC(=O)c3cc(C)n(C)n3)c2)C[C@@H](C)N1 |r,wU:31.36,28.29,46.51,1.0,(19.64,-20.1,;18.31,-19.33,;16.99,-20.1,;15.66,-19.33,;14.33,-20.11,;13,-19.35,;11.67,-20.12,;10.33,-19.36,;10.33,-17.82,;11.65,-17.04,;12.99,-17.8,;14.31,-17.02,;8.99,-17.05,;7.65,-17.84,;6.32,-17.06,;6.32,-15.52,;7.65,-14.76,;7.65,-13.22,;6.31,-12.44,;4.97,-13.22,;3.63,-12.44,;3.63,-10.9,;2.3,-10.13,;4.97,-10.13,;6.31,-10.89,;7.64,-10.12,;7.63,-8.58,;8.98,-10.88,;10.31,-10.11,;11.65,-10.88,;12.98,-10.11,;12.98,-8.57,;11.64,-7.8,;10.3,-8.57,;14.32,-7.8,;15.66,-8.57,;15.66,-10.11,;16.87,-7.62,;16.82,-6.1,;18.27,-5.58,;18.7,-4.1,;19.22,-6.79,;20.76,-6.74,;18.35,-8.07,;8.98,-15.52,;15.64,-17.8,;16.97,-17.03,;16.97,-15.5,;18.31,-17.8,)| | ||
Structure |