Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017335 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.019953±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017335 | |||
n/a | |||
Name | BDBM50017335 | ||
Synonyms: | CHEMBL3288024 | ||
Type | Small organic molecule | ||
Emp. Form. | C37H44FN7O4 | ||
Mol. Mass. | 669.7882 | ||
SMILES | C[C@H]1CN(Cc2cc(ccc2O)-c2cccc(Oc3ncc(F)cc3C(=O)N[C@@H]3CC[C@@H](CC3)NC(=O)c3cc(C)n(C)n3)c2)C[C@@H](C)N1 |r,wU:46.51,1.0,31.36,28.29,(17.3,-40.69,;17.31,-39.15,;16,-38.38,;16.01,-36.85,;14.65,-36.13,;13.33,-36.91,;11.99,-36.15,;10.67,-36.93,;10.67,-38.47,;12.01,-39.23,;13.34,-38.46,;14.68,-39.22,;9.33,-36.17,;8,-36.95,;6.66,-36.18,;6.66,-34.64,;7.99,-33.87,;7.99,-32.33,;6.65,-31.56,;5.32,-32.33,;3.97,-31.56,;3.98,-30.01,;2.64,-29.24,;5.31,-29.24,;6.65,-30,;7.98,-29.23,;7.97,-27.69,;9.32,-29.99,;10.65,-29.22,;11.99,-29.99,;13.32,-29.23,;13.32,-27.68,;11.98,-26.91,;10.65,-27.69,;14.66,-26.91,;16,-27.68,;16,-29.23,;17.22,-26.73,;17.17,-25.21,;18.62,-24.69,;19.05,-23.21,;19.56,-25.91,;21.1,-25.86,;18.7,-27.18,;9.32,-34.63,;17.33,-36.08,;18.66,-36.86,;20,-36.1,;18.65,-38.4,)| | ||
Structure |