| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacylase sirtuin-6 |
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| Ligand | BDBM50017343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1362800 (CHEMBL3295497) |
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| IC50 | 1330000±n/a nM |
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| Citation |  Parenti, MD; Grozio, A; Bauer, I; Galeno, L; Damonte, P; Millo, E; Sociali, G; Franceschi, C; Ballestrero, A; Bruzzone, S; Del Rio, A; Nencioni, A Discovery of novel and selective SIRT6 inhibitors. J Med Chem57:4796-804 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacylase sirtuin-6 |
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| Name: | NAD-dependent protein deacylase sirtuin-6 |
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| Synonyms: | NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6) |
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| Type: | Protein |
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| Mol. Mass.: | 39133.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N6T7 |
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| Residue: | 355 |
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| Sequence: | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
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| BDBM50017343 |
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| n/a |
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| Name | BDBM50017343 |
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| Synonyms: | CHEMBL3288043 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11N7O |
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| Mol. Mass. | 281.2727 |
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| SMILES | O=C(NCc1nc(n[nH]1)-c1cccnc1)c1cnccn1 |
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| Structure | 
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