Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50018011 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1366444 (CHEMBL3296344) |
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IC50 | 150±n/a nM |
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Citation | Deng, X; Kokkonda, S; El Mazouni, F; White, J; Burrows, JN; Kaminsky, W; Charman, SA; Matthews, D; Rathod, PK; Phillips, MA Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem57:5381-94 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | Dhodh | Dihydroorotate dehydrogenase | PYRD_MOUSE |
Type: | PROTEIN |
Mol. Mass.: | 42711.08 |
Organism: | Mus musculus |
Description: | ChEMBL_1366444 |
Residue: | 395 |
Sequence: | MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVR
VISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGIN
LGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQER
DALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTF
LGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
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BDBM50018011 |
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n/a |
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Name | BDBM50018011 |
Synonyms: | Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE |
Type | Small organic molecule |
Emp. Form. | C12H9F3N2O2 |
Mol. Mass. | 270.2073 |
SMILES | C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |
Structure |
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