Reaction Details |
| Report a problem with these data |
Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Ligand | BDBM28817 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1366444 (CHEMBL3296344) |
---|
IC50 | >100000±n/a nM |
---|
Citation | Deng, X; Kokkonda, S; El Mazouni, F; White, J; Burrows, JN; Kaminsky, W; Charman, SA; Matthews, D; Rathod, PK; Phillips, MA Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem57:5381-94 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | Dhodh | Dihydroorotate dehydrogenase | PYRD_MOUSE |
Type: | PROTEIN |
Mol. Mass.: | 42711.08 |
Organism: | Mus musculus |
Description: | ChEMBL_1366444 |
Residue: | 395 |
Sequence: | MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVR
VISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGIN
LGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQER
DALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTF
LGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
|
|
|
BDBM28817 |
---|
n/a |
---|
Name | BDBM28817 |
Synonyms: | 5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | DSM74 | triazolopyrimidine-based compound, DSM74 |
Type | Small organic molecule |
Emp. Form. | C13H10F3N5 |
Mol. Mass. | 293.2472 |
SMILES | Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2ncnc2n1 |
Structure |
|