Ki Summary

Reaction Details

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Target

Neurotensin receptor type 2

Ligand

BDBM50019426

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1364517 (CHEMBL3295314)

62±n/a nM

Citation

Thomas, JB; Giddings, AM; Wiethe, RW; Olepu, S; Warner, KR; Sarret, P; Gendron, L; Longpre, JM; Zhang, Y; Runyon, SP; Gilmour, BP Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J Med Chem57:5318-32 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neurotensin receptor type 2

Name:

Neurotensin receptor type 2

Synonyms:

Type:

PROTEIN

Mol. Mass.:

46280.50

Organism:

Rattus norvegicus

Description:

ChEMBL_1466615

Residue:

416

Sequence:

METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKA
RAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAY
ATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEV
ESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQV
PSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLR
AIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNA
VSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV

BDBM50019426

n/a

Name

BDBM50019426

Synonyms:

CHEMBL3290089

Type

Small organic molecule

Emp. Form.

C31H31ClN4O3

Mol. Mass.

543.056

SMILES

COc1cccc(OC)c1-c1cc(nn1-c1ccnc2cc(Cl)ccc12)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:38:37:35:31.32.33,THB:28:29:35:31.32.33,38:32:29.37.36:35,33:32:29:36.34.35,33:34:29:31.38.32,(32.46,-36.27,;32.94,-34.8,;34.44,-34.48,;35.47,-35.63,;36.98,-35.3,;37.45,-33.84,;36.42,-32.7,;36.9,-31.23,;38.4,-30.91,;34.92,-33.02,;33.58,-31.53,;33.9,-30.02,;32.57,-29.25,;31.42,-30.28,;32.05,-31.69,;31.04,-33.42,;31.81,-34.76,;31.04,-36.09,;29.51,-36.09,;28.74,-34.76,;27.19,-34.76,;26.43,-33.42,;24.89,-33.42,;27.19,-32.09,;28.74,-32.09,;29.51,-33.42,;32.41,-27.72,;33.65,-26.82,;31,-27.09,;30.84,-25.56,;30.47,-23.79,;31.67,-22.96,;32.22,-21.58,;30.93,-20.66,;29.62,-21.49,;29.21,-22.91,;30.03,-23.1,;31.38,-24.05,;32.69,-23.2,)|

Structure