Reaction Details |
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Target | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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Ligand | BDBM50019861 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1361547 (CHEMBL3294871) |
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Kd | 26±n/a nM |
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Citation | Zimmermann, G; Schultz-Fademrecht, C; Küchler, P; Murarka, S; Ismail, S; Triola, G; Nussbaumer, P; Wittinghofer, A; Waldmann, H Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEd prenyl binding site. J Med Chem57:5435-48 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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Name: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
Synonyms: | 3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
Type: | PROTEIN |
Mol. Mass.: | 17418.30 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105761 |
Residue: | 150 |
Sequence: | MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS
RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA
SVLTGNVIIETKFFDDDLLVSTSRVRLFYV
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BDBM50019861 |
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n/a |
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Name | BDBM50019861 |
Synonyms: | CHEMBL3286925 |
Type | Small organic molecule |
Emp. Form. | C53H71FN6O9S |
Mol. Mass. | 987.229 |
SMILES | [H][C@]12CS[C@@H](CCCCC(=O)NCCCOCCOCCOCCCNC(=O)C[C@H](O)C[C@H](O)CCn3c(C(C)C)c(C(=O)Nc4ccccc4)c(c3-c3ccc(F)cc3)-c3ccccc3)[C@@]1([H])NC(=O)N2 |r| |
Structure |
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