Reaction Details |
| Report a problem with these data |
Target | Cytochrome P450 11B1, mitochondrial |
---|
Ligand | BDBM50019893 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1361875 (CHEMBL3293050) |
---|
IC50 | 803±n/a nM |
---|
Citation | Yin, L; Hu, Q; Emmerich, J; Lo, MM; Metzger, E; Ali, A; Hartmann, RW Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J Med Chem57:5179-89 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytochrome P450 11B1, mitochondrial |
---|
Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
|
|
|
BDBM50019893 |
---|
n/a |
---|
Name | BDBM50019893 |
Synonyms: | CHEMBL3287185 | US9745282, 54 |
Type | Small organic molecule |
Emp. Form. | C16H16N2O2 |
Mol. Mass. | 268.3104 |
SMILES | COc1cncc(c1)-c1ccc2N(CCc2c1)C(C)=O |
Structure |
|