| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
|---|
| Ligand | BDBM50341460 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1361875 (CHEMBL3293050) |
|---|
| IC50 | 715±n/a nM |
|---|
| Citation |  Yin, L; Hu, Q; Emmerich, J; Lo, MM; Metzger, E; Ali, A; Hartmann, RW Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J Med Chem57:5179-89 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B1, mitochondrial |
|---|
| Name: | Cytochrome P450 11B1, mitochondrial |
|---|
| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57591.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15538 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
|
|
|
|---|
| BDBM50341460 |
|---|
| n/a |
|---|
| Name | BDBM50341460 |
|---|
| Synonyms: | 8-Pyridin-3-yl-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one | CHEMBL1765205 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H14N2O |
|---|
| Mol. Mass. | 250.2952 |
|---|
| SMILES | O=C1CCc2cc(cc3CCN1c23)-c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
