| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM50020096 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364156 (CHEMBL3292633) |
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| Ki | 40±n/a nM |
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| Citation |  Hanessian, S; Jennequin, T; Boyer, N; Babonneau, V; Soma, U; Mannoury la Cour, C; Millan, MJ; De Nanteuil, G Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists. ACS Med Chem Lett5:550-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52221.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29371 |
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| Residue: | 465 |
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| Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
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| BDBM50020096 |
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| n/a |
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| Name | BDBM50020096 |
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| Synonyms: | CHEMBL3288163 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H39Cl3FN5O4 |
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| Mol. Mass. | 707.062 |
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| SMILES | Cl.CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc12 |r| |
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| Structure | 
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