| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 2 |
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| Ligand | BDBM50020165 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364569 (CHEMBL3295624) |
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| IC50 | >10000±n/a nM |
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| Citation |  Lv, Y; Li, M; Liu, T; Tong, L; Peng, T; Wei, L; Ding, J; Xie, H; Duan, W Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors. ACS Med Chem Lett5:592-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 2 |
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| Name: | Ephrin type-A receptor 2 |
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| Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin receptor | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108260.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1505248 |
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| Residue: | 976 |
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| Sequence: | MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN
DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN
LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG
EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS
PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI
VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG
LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN
SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGG
VAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA
VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF
LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML
RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP
IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM
DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG
SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY
SLLGLKDQVNTVGIPI
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| BDBM50020165 |
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| n/a |
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| Name | BDBM50020165 |
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| Synonyms: | CHEMBL3288526 | US9914707, I-4 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H16N4OS |
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| Mol. Mass. | 396.464 |
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| SMILES | Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12 |
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| Structure | 
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