| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50020878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364645 (CHEMBL3291778) |
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| IC50 | 9690±n/a nM |
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| Citation |  Chen, F; Chai, H; Su, MB; Zhang, YM; Li, J; Xie, X; Nan, FJ Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors. ACS Med Chem Lett5:628-33 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50020878 |
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| n/a |
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| Name | BDBM50020878 |
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| Synonyms: | CHEMBL3287016 | US9216962, CFH398-4 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19N5O4S2 |
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| Mol. Mass. | 397.472 |
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| SMILES | CC(C)[C@H](NC(=O)c1csc(n1)-c1cscn1)C(=O)NCCC(=O)NO |r| |
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| Structure | 
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