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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium-dependent serotonin transporter | ||
| Ligand | BDBM50021112 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1365903 (CHEMBL3296598) | ||
| Ki | 180±n/a nM | ||
| Citation |  Kumar, V; Rahbek-Clemmensen, T; Billesbølle, CB; Jorgensen, TN; Gether, U; Newman, AH Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. ACS Med Chem Lett5:696-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium-dependent serotonin transporter | |||
| Name: | Sodium-dependent serotonin transporter | ||
| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 70322.51 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31645 | ||
| Residue: | 630 | ||
| Sequence: |
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| BDBM50021112 | |||
| n/a | |||
| Name | BDBM50021112 | ||
| Synonyms: | CHEMBL3287654 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C57H69FN6O8S2 | ||
| Mol. Mass. | 1049.322 | ||
| SMILES | CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCCCCN(C)CCC[C@]3(OCc4cc(ccc34)C#N)c3ccc(F)cc3)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wD:42.42,(4.73,-24.46,;6.07,-25.23,;6.07,-26.77,;4.73,-27.54,;3.41,-26.77,;7.4,-27.54,;7.4,-29.08,;8.73,-29.86,;10.07,-29.08,;11.4,-29.84,;11.4,-31.38,;10.07,-32.15,;10.07,-33.69,;11.41,-34.46,;12.75,-33.67,;12.74,-32.14,;14.06,-31.36,;15.4,-32.12,;13.28,-30.02,;14.83,-30.02,;11.41,-35.99,;10.63,-37.32,;9.87,-35.99,;12.75,-36.76,;14.08,-35.99,;15.42,-36.75,;16.75,-35.98,;18.09,-36.74,;19.42,-35.96,;20.75,-36.73,;20.76,-38.27,;22.08,-35.95,;23.42,-36.72,;24.75,-35.94,;26.09,-36.71,;27.42,-35.93,;28.76,-36.7,;30.09,-35.92,;30.08,-34.38,;31.42,-36.69,;32.75,-35.91,;34.09,-36.68,;34.1,-38.22,;32.86,-39.13,;33.34,-40.6,;34.88,-40.58,;35.91,-41.72,;37.41,-41.4,;37.87,-39.93,;36.84,-38.8,;35.35,-39.12,;38.44,-42.53,;39.48,-43.67,;35.19,-37.11,;36.69,-37.51,;37.78,-36.41,;37.36,-34.91,;38.44,-33.81,;35.85,-34.52,;34.77,-35.63,;12.73,-29.07,;14.08,-29.83,;15.41,-29.05,;15.4,-27.5,;14.06,-26.74,;12.73,-27.52,;11.39,-26.76,;10.07,-27.53,;8.73,-26.77,;16.73,-26.72,;16.71,-25.18,;18.04,-24.39,;18.07,-27.47,;19.39,-26.69,)| | ||
| Structure | 
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