| Reaction Details |
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 | Report a problem with these data |
| Target | Estradiol 17-beta-dehydrogenase 2 |
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| Ligand | BDBM50021404 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1363494 (CHEMBL3291985) |
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| IC50 | 54±n/a nM |
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| Citation |  Perspicace, E; Cozzoli, L; Gargano, EM; Hanke, N; Carotti, A; Hartmann, RW; Marchais-Oberwinkler, S Novel, potent and selective 17ß-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities. Eur J Med Chem83:317-37 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estradiol 17-beta-dehydrogenase 2 |
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| Name: | Estradiol 17-beta-dehydrogenase 2 |
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| Synonyms: | 17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_MOUSE | Edh17b2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41847.95 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_104366 |
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| Residue: | 381 |
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| Sequence: | MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFL
LSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGP
GAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGEL
IPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAAL
TMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDY
VHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLL
DYVIKKGFYPQPTPRALRTVH
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| BDBM50021404 |
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| n/a |
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| Name | BDBM50021404 |
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| Synonyms: | CHEMBL3289873 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20FNO3S |
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| Mol. Mass. | 385.452 |
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| SMILES | COc1cccc(-c2cc(C)c(s2)C(=O)N(C)Cc2cccc(O)c2)c1F |
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| Structure | 
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