| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50021712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1368656 |
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| IC50 | 821±n/a nM |
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| Citation |  Blake, JF; Gaudino, JJ; De Meese, J; Mohr, P; Chicarelli, M; Tian, H; Garrey, R; Thomas, A; Siedem, CS; Welch, MB; Kolakowski, G; Kaus, R; Burkard, M; Martinson, M; Chen, H; Dean, B; Dudley, DA; Gould, SE; Pacheco, P; Shahidi-Latham, S; Wang, W; West, K; Yin, J; Moffat, J; Schwarz, JB Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2. Bioorg Med Chem Lett24:2635-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50021712 |
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| n/a |
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| Name | BDBM50021712 |
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| Synonyms: | CHEMBL3298311 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23F4N5O2 |
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| Mol. Mass. | 441.4225 |
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| SMILES | C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](C)c1ccc(c(F)c1)C(F)(F)F |r| |
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| Structure | 
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