Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBeta-3 adrenergic receptor
LigandBDBM50021865
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1369178
EC50 25±n/a nM
Citation McKinnell RMKlein ULinsell MSMoran EJNodwell MBPfeiffer JWThomas GRYu CJacobsen JR Discovery of TD-4306, a long-acting▀2-agonist for the treatment of asthma and COPD. Bioorg Med Chem Lett 24:2871-6 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-3 adrenergic receptor
Name:Beta-2 adrenergic receptor and beta-3 adrenergic receptor
Synonyms:ADRB3 | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:43534.88
Organism:Homo sapiens (Human)
Description:n/a
Residue:408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50021865
n/a
NameBDBM50021865
Synonyms:CHEMBL3298325
TypeSmall organic molecule
Emp. Form.C33H34N4O4
Mol. Mass.550.6475
SMILESCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: