| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
|---|
| Ligand | BDBM50022069 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1367335 (CHEMBL3300366) |
|---|
| EC50 | 27400±n/a nM |
|---|
| Citation |  Bobileva, O; Bokaldere, R; Gailite, V; Kaula, I; Ikaunieks, M; Duburs, G; Petrovska, R; Mandrika, I; Klovins, J; Loza, E Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists. Bioorg Med Chem22:3654-69 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hydroxycarboxylic acid receptor 2 |
|---|
| Name: | Hydroxycarboxylic acid receptor 2 |
|---|
| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 41868.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
|---|
| Residue: | 363 |
|---|
| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
|
|
|
|---|
| BDBM50022069 |
|---|
| n/a |
|---|
| Name | BDBM50022069 |
|---|
| Synonyms: | CHEMBL3299016 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17ClN2O3 |
|---|
| Mol. Mass. | 356.803 |
|---|
| SMILES | OC(=O)C1=C(CCCC1)NC(=O)\C=C\c1cc2ccccc2nc1Cl |t:3| |
|---|
| Structure | 
|
|---|
Search and Browse
