Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50022102 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1367458 (CHEMBL3300911) |
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Ki | 0.830000±n/a nM |
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Citation | Ghorab, MM; Alsaid, MS; Ceruso, M; Nissan, YM; Supuran, CT Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties. Bioorg Med Chem22:3684-95 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50022102 |
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n/a |
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Name | BDBM50022102 |
Synonyms: | CHEMBL3298838 |
Type | Small organic molecule |
Emp. Form. | C24H20BrN7O4S |
Mol. Mass. | 582.429 |
SMILES | CCOC(=O)C1=C(N)N=C2N(C=Nc3c2c(cn3-c2ccc(cc2)S(N)(=O)=O)-c2ccc(Br)cc2)N=C1 |c:5,8,11,39| |
Structure |
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