Reaction Details |
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Target | Cytochrome P450 2C9 |
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Ligand | BDBM50022759 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1368993 |
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IC50 | >30000±n/a nM |
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Citation | Turlington, M; Malosh, C; Jacobs, J; Manka, JT; Noetzel, MJ; Vinson, PN; Jadhav, S; Herman, EJ; Lavreysen, H; Mackie, C; Bartolomé-Nebreda, JM; Conde-Ceide, S; Martín-Martín, ML; Tong, HM; López, S; MacDonald, GJ; Steckler, T; Daniels, JS; Weaver, CD; Niswender, CM; Jones, CK; Conn, PJ; Lindsley, CW; Stauffer, SR Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). J Med Chem57:5620-37 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C9 |
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Name: | Cytochrome P450 2C9 |
Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 55636.33 |
Organism: | Homo sapiens (Human) |
Description: | P11712 |
Residue: | 490 |
Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
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BDBM50022759 |
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n/a |
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Name | BDBM50022759 |
Synonyms: | CHEMBL3298273 |
Type | Small organic molecule |
Emp. Form. | C15H13FN2O2 |
Mol. Mass. | 272.2743 |
SMILES | Fc1cccc(COc2ccc3C(=O)NCCc3n2)c1 |
Structure |
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