Reaction Details |
| Report a problem with these data |
Target | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
---|
Ligand | BDBM50023350 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1459634 (CHEMBL3369891) |
---|
Ki | 45±n/a nM |
---|
Citation | Ferla, S; Aboraia, AS; Brancale, A; Pepper, CJ; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. J Med Chem57:7702-15 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
---|
Name: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
Synonyms: | 25-OHD-1 alpha-hydroxylase | 25-hydroxyvitamin D(3) 1-alpha-hydroxylase | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_MOUSE | Calcidiol 1-monooxygenase | Cyp27b | Cyp27b | Cyp27b1 | Cyp40 | Cytochrome P450 subfamily XXVIIB polypeptide 1 | Cytochrome P450C1 alpha | Cytochrome P450VD1-alpha | Cytochrome p450 27B1 | VD3 1A hydroxylase |
Type: | PROTEIN |
Mol. Mass.: | 56238.51 |
Organism: | Mus musculus |
Description: | ChEMBL_109473 |
Residue: | 507 |
Sequence: | MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSR
LHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRH
QRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLP
GLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPN
WLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFRE
KVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHG
TALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQ
FPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPE
PGALPIKPMTRTVLVPERSINLQFVDR
|
|
|
BDBM50023350 |
---|
n/a |
---|
Name | BDBM50023350 |
Synonyms: | CHEMBL3329771 |
Type | Small organic molecule |
Emp. Form. | C26H24FN3O |
Mol. Mass. | 413.4867 |
SMILES | Fc1ccc(CCc2ccc(cc2)C(=O)NCC(c2ccccc2)n2ccnc2)cc1 |
Structure |
|