| Reaction Details |
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 | Report a problem with these data |
| Target | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Ligand | BDBM50370925 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1459633 (CHEMBL3369890) |
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| IC50 | 6.5±n/a nM |
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| Citation |  Ferla, S; Aboraia, AS; Brancale, A; Pepper, CJ; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. J Med Chem57:7702-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Name: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Synonyms: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1 |
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| Type: | Protein |
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| Mol. Mass.: | 58889.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07973 |
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| Residue: | 514 |
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| Sequence: | MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
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| BDBM50370925 |
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| n/a |
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| Name | BDBM50370925 |
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| Synonyms: | CHEMBL1627233 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H41NO3S |
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| Mol. Mass. | 483.706 |
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| SMILES | C[C@H](CC=S(N)(=O)c1ccccc1)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| |
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| Structure | 
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