| Reaction Details |
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 | Report a problem with these data |
| Target | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Ligand | BDBM50023363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1459633 (CHEMBL3369890) |
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| Ki | 21±n/a nM |
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| Citation |  Ferla, S; Aboraia, AS; Brancale, A; Pepper, CJ; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. J Med Chem57:7702-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Name: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Synonyms: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1 |
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| Type: | Protein |
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| Mol. Mass.: | 58889.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07973 |
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| Residue: | 514 |
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| Sequence: | MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
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| BDBM50023363 |
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| n/a |
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| Name | BDBM50023363 |
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| Synonyms: | CHEMBL3360784 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H36N2O2 |
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| Mol. Mass. | 396.5655 |
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| SMILES | [H][C@@]1([#6]-[#6][C@@]2([H])\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1)[#6@H](-[#6])-[#6]-n1ccnc1 |r| |
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| Structure | 
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