| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Ligand | BDBM50023925 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1435206 (CHEMBL3390091) |
|---|
| IC50 | 107±n/a nM |
|---|
| Citation |  Takahashi, E; Arai, T; Akahira, M; Nakajima, M; Nishimura, K; Omori, Y; Kumagai, H; Suzuki, T; Hayashi, R The discovery of potent glycine transporter type-2 inhibitors: design and synthesis of phenoxymethylbenzamide derivatives. Bioorg Med Chem Lett24:4603-6 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Name: | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 87438.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
|---|
| Residue: | 797 |
|---|
| Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
|
|
|
|---|
| BDBM50023925 |
|---|
| n/a |
|---|
| Name | BDBM50023925 |
|---|
| Synonyms: | CHEMBL3325506 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25F3N2O2 |
|---|
| Mol. Mass. | 406.4413 |
|---|
| SMILES | CCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
