Reaction Details |
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Target | Retinol-binding protein 4 |
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Ligand | BDBM50026248 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1441245 (CHEMBL3380010) |
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IC50 | 3.9±n/a nM |
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Citation | Cioffi, CL; Dobri, N; Freeman, EE; Conlon, MP; Chen, P; Stafford, DG; Schwarz, DM; Golden, KC; Zhu, L; Kitchen, DB; Barnes, KD; Racz, B; Qin, Q; Michelotti, E; Cywin, CL; Martin, WH; Pearson, PG; Johnson, G; Petrukhin, K Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease. J Med Chem57:7731-57 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinol-binding protein 4 |
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Name: | Retinol-binding protein 4 |
Synonyms: | PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4 |
Type: | Protein |
Mol. Mass.: | 23008.75 |
Organism: | Homo sapiens (Human) |
Description: | P02753 |
Residue: | 201 |
Sequence: | MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIV
AEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGND
DHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLA
RQYRLIVHNGYCDGRSERNLL
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BDBM50026248 |
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n/a |
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Name | BDBM50026248 |
Synonyms: | CHEMBL3358465 |
Type | Small organic molecule |
Emp. Form. | C26H24F3N3O4S |
Mol. Mass. | 531.547 |
SMILES | FC(F)(F)c1ccccc1C1CCN(CC1)C(=O)Nc1ccccc1C(=O)NS(=O)(=O)c1ccccc1 |
Structure |
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