Reaction Details |
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Target | Cytochrome P450 2C19 |
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Ligand | BDBM50026255 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1441250 (CHEMBL3380640) |
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IC50 | 31000±n/a nM |
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Citation | Cioffi, CL; Dobri, N; Freeman, EE; Conlon, MP; Chen, P; Stafford, DG; Schwarz, DM; Golden, KC; Zhu, L; Kitchen, DB; Barnes, KD; Racz, B; Qin, Q; Michelotti, E; Cywin, CL; Martin, WH; Pearson, PG; Johnson, G; Petrukhin, K Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease. J Med Chem57:7731-57 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C19 |
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Name: | Cytochrome P450 2C19 |
Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
Type: | Enzyme |
Mol. Mass.: | 55935.47 |
Organism: | Homo sapiens (Human) |
Description: | P33261 |
Residue: | 490 |
Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
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BDBM50026255 |
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n/a |
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Name | BDBM50026255 |
Synonyms: | CHEMBL3359017 |
Type | Small organic molecule |
Emp. Form. | C22H20F4N2O3 |
Mol. Mass. | 436.3994 |
SMILES | [H][C@@]12C[C@@H](C[C@]1([H])CN(C2)C(=O)Nc1ccc(F)cc1C(O)=O)c1ccccc1C(F)(F)F |r| |
Structure |
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