| Reaction Details |
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 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose-5-phosphate synthase |
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| Ligand | BDBM50026326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1441266 (CHEMBL3380656) |
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| Ki | 5600±n/a nM |
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| Citation |  Masini, T; Hirsch, AK Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents. J Med Chem57:9740-63 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-deoxy-D-xylulose-5-phosphate synthase |
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| Name: | 1-deoxy-D-xylulose-5-phosphate synthase |
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| Synonyms: | 1-deoxy-D-xylulose-5-phosphate synthase | 1-deoxyxylulose-5-phosphate synthase | DXP synthase | DXPS | DXS_ECO27 | dxs |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67649.22 |
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| Organism: | Escherichia coli O127:H6 (strain E2348/69 / EPEC) |
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| Description: | ChEMBL_109718 |
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| Residue: | 620 |
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| Sequence: | MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLND
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLLDFFIPQGTQEEM
RAELGLDATGMEAKIKAWLA
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| BDBM50026326 |
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| n/a |
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| Name | BDBM50026326 |
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| Synonyms: | CHEMBL3305928 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H13O4P |
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| Mol. Mass. | 180.1388 |
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| SMILES | CCCCOP(O)(=O)C(C)=O |
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| Structure | 
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