| Reaction Details |
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 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose-5-phosphate synthase |
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| Ligand | BDBM50373886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1441270 (CHEMBL3380660) |
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| IC50 | 430000±n/a nM |
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| Citation |  Masini, T; Hirsch, AK Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents. J Med Chem57:9740-63 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-deoxy-D-xylulose-5-phosphate synthase |
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| Name: | 1-deoxy-D-xylulose-5-phosphate synthase |
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| Synonyms: | 1-deoxy-D-xylulose-5-phosphate synthase | 1-deoxyxylulose-5-phosphate synthase | DXP synthase | DXPS | DXS_DEIRA | dxs |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67636.69 |
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| Organism: | Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 /LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) |
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| Description: | ChEMBL_109727 |
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| Residue: | 629 |
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| Sequence: | MNELPGTSDTPLLDQIHGPKDLKRLSREQLPALTEELRGEIVRVCSRGGLHLASSLGAVD
IITALHYVLDSPRDRILFDVGHQAYAHKILTGRRDQMADIKKEGGISGFTKVSESEHDAI
TVGHASTSLANALGMALARDAQGKDFHVAAVIGDGSLTGGMALAALNTIGDMGRKMLIVL
NDNEMSISENVGAMNKFMRGLQVQKWFQEGEGAGKKAVEAVSKPLADFMSRAKNSTRHFF
DPASVNPFAAMGVRYVGPVDGHNVQELVWLLERLVDLDGPTILHIVTTKGKGLSYAEADP
IYWHGPAKFDPATGEYVPSSAYSWSAAFGEAVTEWAKTDPRTFVVTPAMREGSGLVEFSR
VHPHRYLDVGIAEEVAVTTAAGMALQGMRPVVAIYSTFLQRAYDQVLHDVAIEHLNVTFC
IDRAGIVGADGATHNGVFDLSFLRSIPGVRIGLPKDAAELRGMLKYAQTHDGPFAIRYPR
GNTAQVPAGTWPDLKWGEWERLKGGDDVVILAGGKALDYALKAAEDLPGVGVVNARFVKP
LDEEMLREVGGRARALITVEDNTVVGGFGGAVLEALNSMNLHPTVRVLGIPDEFQEHATA
ESVHARAGIDAPAIRTVLAELGVDVPIEV
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| BDBM50373886 |
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| n/a |
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| Name | BDBM50373886 |
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| Synonyms: | 3-Deazathiamine | CHEMBL401772 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17N3OS |
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| Mol. Mass. | 263.359 |
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| SMILES | Cc1c(Cc2cnc(C)nc2N)csc1CCO |
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| Structure | 
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