Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase 1 |
---|
Ligand | BDBM50026643 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1435381 (CHEMBL3383455) |
---|
IC50 | 800±n/a nM |
---|
Citation | Giacomini, E; Nebbioso, A; Ciotta, A; Ianni, C; Falchi, F; Roberti, M; Tolomeo, M; Grimaudo, S; Cristina, AD; Pipitone, RM; Altucci, L; Recanatini, M Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity. ACS Med Chem Lett5:973-8 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 1 |
---|
Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
BDBM50026643 |
---|
n/a |
---|
Name | BDBM50026643 |
Synonyms: | CHEMBL3335369 |
Type | Small organic molecule |
Emp. Form. | C25H32N2O6 |
Mol. Mass. | 456.5314 |
SMILES | COc1cc(OC)cc(\C=C\c2ccc(OC)c(NC(=O)CCCCCCC(=O)NO)c2)c1 |
Structure |
|