| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADH] |
|---|
| Ligand | BDBM8726 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1436802 (CHEMBL3386587) |
|---|
| IC50 | 630±n/a nM |
|---|
| Citation |  Naik, M; Ghorpade, S; Jena, LK; Gorai, G; Narayan, A; Guptha, S; Sharma, S; Dinesh, N; Kaur, P; Nandishaiah, R; Bhat, J; Balakrishnan, G; Humnabadkar, V; Ramachandran, V; Naviri, LK; Khadtare, P; Panda, M; Iyer, PS; Chatterji, M 2-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis. ACS Med Chem Lett5:1005-9 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Enoyl-[acyl-carrier-protein] reductase [NADH] |
|---|
| Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] |
|---|
| Synonyms: | Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28526.00 |
|---|
| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
|---|
| Description: | P9WGR1 |
|---|
| Residue: | 269 |
|---|
| Sequence: | MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL
|
|
|
|---|
| BDBM8726 |
|---|
| n/a |
|---|
| Name | BDBM8726 |
|---|
| Synonyms: | 5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H7Cl3O2 |
|---|
| Mol. Mass. | 289.542 |
|---|
| SMILES | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
