| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50027491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1442973 (CHEMBL3378918) |
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| EC50 | 3900±n/a nM |
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| Citation |  Balsera, B; Mulet, J; Fernández-Carvajal, A; de la Torre-Martínez, R; Ferrer-Montiel, A; Hernández-Jiménez, JG; Estévez-Herrera, J; Borges, R; Freitas, AE; López, MG; García-López, MT; González-Muńiz, R; Pérez de Vega, MJ; Valor, LM; Svobodová, L; Sala, S; Sala, F; Criado, M Chalcones as positive allosteric modulators ofa7 nicotinic acetylcholine receptors: a new target for a privileged structure. Eur J Med Chem86:724-39 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) |
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| Type: | n/a |
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| Mol. Mass.: | 56448.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHRNA7 (NACHRA7) |
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| Residue: | 502 |
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| Sequence: | MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50027491 |
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| n/a |
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| Name | BDBM50027491 |
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| Synonyms: | CHEMBL3335599 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16O5 |
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| Mol. Mass. | 300.3059 |
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| SMILES | COc1ccc(\C=C\C(=O)c2cc(O)ccc2O)c(OC)c1 |
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| Structure | 
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