| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM50028013 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1439804 (CHEMBL3386766) |
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| IC50 | 900±n/a nM |
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| Citation |  Mabkhot, YN; Barakat, A; Yousuf, S; Choudhary, MI; Frey, W; Ben Hadda, T; Mubarak, MS Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis,ß-glucuronidase inhibition activity, crystal structure, and POM analyses. Bioorg Med Chem22:6715-25 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase) |
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| Type: | Protein |
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| Mol. Mass.: | 74736.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 651 |
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| Sequence: | MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
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| BDBM50028013 |
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| n/a |
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| Name | BDBM50028013 |
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| Synonyms: | CHEMBL3360798 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H42O8S2 |
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| Mol. Mass. | 630.812 |
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| SMILES | CCOC(OCC)(OCC)\C=C\C(=O)c1sc2sc(C(=O)\C=C\C(OCC)(OCC)OCC)c(-c3ccccc3)c2c1C |
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| Structure | 
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