| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-17 |
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| Ligand | BDBM50265079 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1433225 (CHEMBL3388192) |
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| IC50 | >30000±n/a nM |
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| Citation |  Fabre, B; Ramos, A; de Pascual-Teresa, B Targeting matrix metalloproteinases: exploring the dynamics of the s1' pocket in the design of selective, small molecule inhibitors. J Med Chem57:10205-19 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-17 |
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| Name: | Matrix metalloproteinase-17 |
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| Synonyms: | MMP-17 | MMP17 | MMP17_HUMAN | MT-MMP 4 | MT4-MMP | MT4MMP | MTMMP4 | Matrix metalloproteinase 17 | Matrix metalloproteinase-17 | Membrane-type matrix metalloproteinase 4 | Membrane-type-4 matrix metalloproteinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66652.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1433225 |
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| Residue: | 603 |
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| Sequence: | MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFG
YLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQ
ARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG
SAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGM
DLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESV
SPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRD
RHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRP
VSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLD
DAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAE
GPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQA
LTL
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| BDBM50265079 |
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| n/a |
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| Name | BDBM50265079 |
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| Synonyms: | (4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-quinazolin-3-ylmethyl]-benzoic acid) | 4-((1-methyl-2,4-dioxo-6-(3-phenylprop-1-ynyl)-1,2-dihydroquinazolin-3(4H)-yl)methyl)benzoic acid | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CHEMBL496942 | MMP Inhibitor, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20N2O4 |
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| Mol. Mass. | 424.448 |
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| SMILES | Cn1c2ccc(cc2c(=O)n(Cc2ccc(cc2)C(O)=O)c1=O)C#CCc1ccccc1 |
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| Structure | 
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