| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50028964 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1433266 (CHEMBL3388804) |
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| IC50 | 45±n/a nM |
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| Citation |  Trieselmann, T; Wagner, H; Fuchs, K; Hamprecht, D; Berta, D; Cremonesi, P; Streicher, R; Luippold, G; Volz, A; Markert, M; Nar, H Potent cholesteryl ester transfer protein inhibitors of reduced lipophilicity: 1,1'-spiro-substituted hexahydrofuroquinoline derivatives. J Med Chem57:8766-76 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50028964 |
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| n/a |
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| Name | BDBM50028964 |
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| Synonyms: | CHEMBL3360278 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34F3NO2 |
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| Mol. Mass. | 473.5703 |
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| SMILES | CC(C)c1nc2CC(C)(C)C[C@H](O)c2c2c1[C@H](OC21CCCCC1)c1ccc(cc1)C(F)(F)F |r| |
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| Structure | 
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