| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 4 |
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| Ligand | BDBM50029089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1435524 (CHEMBL3385344) |
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| IC50 | 600±n/a nM |
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| Citation |  Rodriguez Lavado, J; Sestito, SE; Cighetti, R; Aguilar Moncayo, EM; Oblak, A; Lain?cek, D; Jiménez Blanco, JL; García Fernández, JM; Ortiz Mellet, C; Jerala, R; Calabrese, V; Peri, F Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators. J Med Chem57:9105-23 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 4 |
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| Name: | Toll-like receptor 4 |
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| Synonyms: | TLR4 | TLR4-MD2 | TLR4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95675.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1436169 |
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| Residue: | 839 |
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| Sequence: | MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
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| BDBM50029089 |
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| n/a |
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| Name | BDBM50029089 |
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| Synonyms: | CHEMBL3360821 |
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| Type | Small organic molecule |
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| Emp. Form. | C62H111ClN12O15 |
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| Mol. Mass. | 1300.069 |
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| SMILES | Cl.[H][C@]1(O[C@H]2O[C@H](Cn3cc(CN(CCN)CCN)nn3)[C@@H](OC(=O)CCCCC)[C@H](OC(=O)CCCCC)[C@@H]2OC(=O)CCCCC)O[C@H](Cn2cc(CN(CCN)CCN)nn2)[C@@H](OC(=O)CCCCC)[C@H](OC(=O)CCCCC)[C@H]1OC(=O)CCCCC |r| |
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| Structure | 
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